Many of you have probably heard about the editor of CRISPR genome, thanks to which it has already made many discoveries. However, according to scientists from Stanford University, some people may have a natural immunity to “interference” in our DNA, which casts doubt on the feasibility of this technology.
During a series of experiments, the experts from Stanford examined blood samples from 22 infants and 12 adults for the detection of antibodies to Cas9. Recall that Cas9 is used for cutting the DNA helix, with what is happening and actually edit. Experts found out that 65% of participants have a blood T-cells (immune cells) which can protect DNA from the effects of Cas9. Thus, we can conclude that the “panacea” of genetic diseases may be ineffective in more than half of the people. As stated by one of the authors of Matthew Porteus in an interview with bioRxiv,
“Our own immune system will prevent safe and effective use of CRISPR and may even lead to serious toxic lesions of the body. After all, the most common today, the Cas9 protein derived from Staphylococcus aureus and pyogenic Streptococcus. This may explain the fact of where our body is immune to such a young technology. Because both these bacteria attack humans for hundreds of years. However, the advent of new technology, CRISPR could solve the problem, because the potential for genome editing is enormous.”